(Ancylostoma spp., Uncinaria stenocephala)
Hookworms are nematodes that infect domestic and wild canids, felids and primates. Dogs become infected with ensheathed third-stage larvae via the percutaneous (skin), oral or trans-mammary routes (Ancylostoma caninum only). They are zoonotic.
|Parasite: Ancylostoma caninum, Ancylostoma ceylanicum, Ancylostoma braziliense, Uncinaria stenocephala|
|Common name: Hookworm|
|Host: Dogs, cats, wild canids and felids, primates (including humans)|
|Pre-patent period: 2 to 4 weeks depending on site of infection|
|Location of adults: Small intestine|
|Transmission route: Ingestion of third stage larva (all), percutaneous (all) and via trans-mammary route (A. caninum only)|
A.caninum is found in wet and dry regions of the tropics and subtropics. Ancylostoma ceylanicum is found in the wet tropics and subtropics of Southeast Asia, China, India, and Oceania. Ancylostoma braziliense is found in the wet tropics of Central and South America, Malaysia, Indonesia, and northern Australia. Uncinaria stenocephala is usually found in temperate, cooler climates in sub-tropical regions.
In puppies (as young as 10 days old for A. caninum), diarrhoea, often bloody, anaemia, hypoproteinaemia and death may ensue. In older dogs, non-regenerative iron deficiency anaemia may result.
Detection of strongyle eggs (Fig 1) on standard faecal flotation (SOP 1) using saturated salt or sodium nitrate solution (S.G. 1.20). Immature worms may still produce clinical disease (i.e. no eggs observed in faeces). In this case, treatment and examination of expelledelled worms is recommended (Figs 22 and 3).
For anthelmintic treatment options refer to Table 1.
Anthelmintic therapy should be combined with supportive care (e.g. fluid and electrolyte therapy, blood transfusion, iron supplementation, high protein diet), where necessary.
Puppies should be treated with a registered anthelmintic labelled for use in puppies at 2 weeks of age (to prevent vertically acquired infections becoming patent) and then every 2 weeks until 8 weeks of age. Treat the dam at the same time. Following this, dogs should be dewormed fortnightly, or if using moxidectin, then monthly (2.5 mg/kg topically). Refer to Table 1 for details.
Puppies should be tested for parasites (SOP 1) during routine consultations (e.g. vaccinations) and at least every 3 months thereafter to monitor the efficacy of the parasite control regime and owner compliance.
For further control options, refer to the General Considerations and Recommendations section.
N.B. Off-label use of anthelmintics that significantly reduce the burden of trans-mammary transmission of A. caninum from dam to pups has been described in published literature. These include::
All animal hookworms are zoonotic and may cause cutaneous larva migrans in people. Penetration of the ensheathed larvae produce a mild, self-limiting pruritic rash called ‘ground itch’. Ancylostoma braziliense may produce ‘creeping eruptions’, highly pruritic mobile linear or serpent-like dermal lesions. In Asia and Oceania, dogs act as reservoirs for A. ceylanicum , which produces patent (egg-positive) symptomatic hookworm disease in humans. Non-patent immature A. caninum worms may cause eosinophilic enteritis in humans. Most A. caninum infections in humans appear asymptomatic.
 Kramer F, Hammerstein R, Stoye M, Epe C. Investigations into the prevention of prenatal and lactogenic Toxocara canis infections in puppies by application of moxidectin to the pregnant dog. J Vet Med B Infect Dis Vet Public Health. 2006;53:218-223.
 Burke TM, Roberson EL. Fenbendazole treatment of pregnant bitches to reduce prenatal and lactogenic infections of Toxocara canis and Ancylostoma caninum in pups. J Am Vet Med Assoc. 1983;183:987-990.
 Stoye M, Meyer O, Schnieder T. The effect of ivermectin on reactivated somatic larva of Ancylostoma caninum Ercolani 1859 (Ancylostomidae) in the pregnant dogdog. Zentralbl Veterinarmed. 1989;36:271-278.
 Traub, RJ. Ancylostoma ceylanicum – a re-emerging but neglected parasitic zoonosis. Int J Parasitol. 2013;43:1009-1015.